SOLUBLE SUPPRESSION OF TUMORIGENICITY-2 (sST2) LEVEL AS PROGNOSTIC MARKER IN NON-ST SEGMENT ELEVATION MYOCARDIAL INFARCT

Sherly Purnamawaty

Abstract


Acute myocardial infarction (IMA) is the most severe manifestation of coronary arterial disease and about 60%-75% of IMA is NSTEMI. Complications are associated with high mortality rates so predicting the development of complications in NSTEMI will help physicians improve risk stratification and determine optimal treatment. Suppression of tumorigenicity-2 (ST2) is a family of interleukin-1 (IL-1) receptors. Ischemia, injury and myocardial infarction will cause cardiomyocytes release sST2, associated with a worse prognosis. This study used a prospective cohort method conducted on NSTEMI patients treated at Pusat Jantung Terpadu of RSUP. Dr. Wahidin Sudirohusodo during the period of March 2019. A sample of 42 patients was obtained. All patients were tested for sST2 levels by immunochromatography and followed up during hospitalization. Data taken during follow-up are the development of heart failure, arrhythmia, cardiogenic shock, sudden cardiac arrest, length of stay, and outcome. Data were analyzed statistically by Mann Whitney and Spearman test. The results of sST2 level in NSTEMI with heart failure were 114.09±92.01 ng/mL and without heart failure was 58.94±57.75 ng/mL (p=0.014). There was no significant difference between sST2 levels in NSTEMI with complications of arrhythmias, cardiogenic shock, and sudden cardiac arrest compared to patients without those complications (p>0.05). The level of sST2 was significantly higher in NSTEMI patients who died (164.05±77.35 ng/ml) than those survived (72.55±73.15 (p=0.027). There was no correlation between sST2 levels and length of stay (p=0.947). It was concluded that sST2 levels can be a prognostic marker for NSTEMI particularly heart failure and outcome.

Keywords


NSTEMI, sST2, heart failure, arrhythmia, cardiogenic shock, sudden cardiac arrest, mortality

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1533

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