Correlation between Procalcitonin, Erythrocyte Sedimentation Rate and Red-Cell Distribution Width with Outcomes in ALL

Nathalya Dwi Kartikasari, I. G.A.A Putri Sri Rejeki, I Dewa Gede Ugrasena

Abstract


Acute Lymphoblastic Leukemia (ALL) increases annually and the incidence is mostly found in children. Its high failure rate
is due to infection in the induction phase of chemotherapy. One of the strategies is laboratory testing to determine
prognostic factors or predictors that can help clinicians determine therapy and outcomes in ALL. Research related to
Procalcitonin (PCT), Erythrocyte Sedimentation Rate (ESR), and Red-cell Distribution Width (RDW) test in ALL children with
poor outcomes has never been performed at Dr. Soetomo Hospital, Surabaya. This study aimed to determine the correlation
of some infection parameters (PCT, ESR, and RDW) with outcomes in ALL. This was a cross-sectional study in the Pediatric
Ward of the Dr. Soetomo Hospital in the period of June-August 2019. A total of 34 ALL patients after the induction phase of
chemotherapy according to ALL-2018 protocol were included in this research. Procalcitonin, ESR, and RDW were
determined using an ELFA method, photometrical capillary stopped-flow kinetic method, and flow cytometry method. The
age of the study subjects ranged from 3 months to 16 years old, 32 patients (94.1%) were categorized as ALL-L1, 23 patients
(67.6%) used protocol of high-risk group stratification. The study subjects were divided into 10 patients with poor outcomes
and 24 patients with a good outcome. Procalcitonin was (2.66±13.15), ESR was (22.65±19.18), and RDW was (14.97±2.727).
There was a significant correlation between PCT and outcomes.


Keywords


Acute lymphoblastic leukemia, children, procalcitonin, erythrocyte sedimentation rate, red-cell distribution width, outcomes

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References


Satyanarayana L, Asthana S, Labani P. Childhood

cancer incidence in India: A review of populationbased cancer registries. Indian Pediatrics, 2018; 59:

-20.

Terwilliger T, Abdul-Hay M. Acute lymphoblastic

leukemia: A comprehensive review and 2017 update.

Blood Cancer Journal, 2017; 7(6): e577.

Data Divisi Hematologi Onkologi Departemen/SMF

Ilmu Kesehatan Anak RSUD Dr. Soetomo tahun 2013

(Data tidak dipublikasikan).

Qu Z, Fang B, Ma G, Jiang J, Wang X, et al. Significance

of procalcitonin in bacterial infections among acute

leukemia patients with post-chemotherapy

agranulocytosis. Srpski Arhiv Za Celokupno Lekarstvo,

; 145(7–8): 382–386.

Tas F, Erturk K. Elevated erythrocyte sedimentation

rate is associated with metastatic disease and worse

survival in patients with cutaneous malignant

melanoma. Molecular and Clinical Oncology, 2017; 7:

-1146.

Jandial A, Kumar S, Bhala A, Navneet S, Varma N,

Varma S. Elevated red cell distribution width as

prognostic marker in severe sepsis: A prospective

observational study. Indian J Crit care Med 2017; 21:

-62.

Montagnana M, Danese E. Red cell distribution width

and cancer. Annals of Translational Medicine, 2016;

(20): 399–399.

Li B, You Z, Xiong XZ, Zhou Y, Wu SJ, et al. Elevated red

cell distribution width predict poor prognosis in hilar

cholangiocarcinoma. Oncotarget, 2017; 8(65):

-109477.

Kiriu T, Yamamoto M, Nagano T, Koyama K, Katsurada

M, et al. Prognostic value of red blood cell distribution

width in non-small cell lung cancer treated with anti

programm cell death-1 antibody. In-vivo, 2019; 33:

-220.

Durmas B, Watek M, Wollny T, Niemirowicz K, Marzec

M, et al. Utility of blood procalcitonin concentration in

management of cancer patients with infections. Onco

Targets Ther, 2016; 9: 469-475.

Suryawan N, Idjradinata P, Reniarti L. Hubungan

subtipe sel limfosit dengan tingkat remisi

pascakemoterapi fase induksi leukemia akut. Sari Pediatri, 2017; 18(6): 448.

Poernomo B, Ugrasena IG, Supriyadi. Buku ajar

hematologi-onkologi anak edisi revisi. 2018; Bab 7

(276-285).

Widijanti A. Pengukuran prokalsitonin serum dengan

test cepat FIA untuk deteksi sepsis. Materi PK Update

Malang, FK Unbraw, 2019; 64-68.

Rafsanjani KA, Fallahi M, Kiumarsi A, Falahati V,

Moghaddam S. The association between red cell

distribution width and mortality in pediatric acute

lymphoblastic leukemia. Journal of Neoplasm, 2018;

(02): 1–3.

Protokol Nasional ALL 2018. Ikatan Dokter Anak

Indonesia (data tidak dipublikasikan).

Rytting M, Jabbour E, O'Brien S, Kantarjian H. Review

article acute lymphoblastic leukemia in adolescents and

young adults. Wiley Online Library, 2017; 7(6): e577.

Mohanty J, Nagababu E, Rifkind J. Red blood cell

oxidative strees impairs oxygen delivery and induces

red blood cell aging. PubMed Central, 2014; 28; 5: 84.

Ai L, Mu S, Hu Y. Prognostic role of RDW in hematology

malignancies: A systematic review and meta-analysis,

primary research. BMC-Cancer Cell International,

; 18: 61.

Kapoor R ,Simalti A, Roy S, Agarwal P. Hematological

profile of febrile neutropenia in acute leukemia and

utility of serum procalcitonin levels in neutropenic

patients. Indian J. Crit Care Med, 2018; 22(5): 336-339.

Devina T, Lubis M, Mutiara E. Red cell distribution

width and mortality in pediatric sepsis. Paediatric

Indonesia, 2016; 56(6): 320-324.

Litao M, Kamat D. Red blood cell distribution width

clinical use beyond hematology, back to basics.

Pediatrics in Review, 2018; 39(4): 204-209.

Li J, Yang J, Gong F, Chen Q. Relationship of red blood

cell distribution width with cancer mortality in

hospital. Biomed Research International, 2018; 1: 1-8.




DOI: http://dx.doi.org/10.24293/ijcpml.v27i3.1580

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