Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome
DOI:
https://doi.org/10.24293/ijcpml.v27i1.1609Keywords:
Acute coronary syndrome, platelet indices, IPF, STEMI, NSTEMI, unstable anginaAbstract
Acute Coronary Syndrome (ACS) includes ST-Elevation Myocardial Infarction (STEMI), non-ST Elevation Myocardial Infarction (NSTEMI), and Unstable Angina (UA). Platelet plays an essential role in ACS pathogenesis. Immature Platelet Fraction (IPF) and platelet indices can predict platelet activations. Platelet indices consist of platelet count, Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), plateletcrit (Pct). This study aimed to analyze the differences of IPF and platelet indices among ACS patients. This study was an observational analytical cross-sectional study conducted in Dr. Soetomo Hospital during May-September 2019. The subjects consisted of 30-STEMI, 25-NSTEMI, and 24-UA patients. The EDTA-samples were measured for platelet indices and IPF using Sysmex XN-1000. The differences between IPF and platelet indices among STEMI, NSTEMI, and UA patients were analyzed using Kruskal-Wallis and Mann-Whitney test. The IPF values were significantly higher in STEMI patients than NSTEMI and UA patients. The IPF values of NSTEMI patients were higher than UA patients. The MPV, PDW, and P-LCR were significantly higher in STEMI and NSTEMI compared to UA. The MPV, PDW, and P-LCR values of NSTEMI patients were significantly higher than UA patients. The significant differences between STEMI and NSTEMI toward UA might be caused by the more severe thrombotic conditions in myocardial infarction patients than UA. The IPF values were significantly different among each type of ACS patients gave an opportunity using this parameter to differentiate the ACS types. The MPV, PDW, and P-LCR were significantly higher in myocardial infarction patients than UA patients, which also allowed them to use those parameters to differentiate both conditions.
Downloads
References
Jayaraj JC, Davatyan K, Subramanian SS, Priya J. Epidemiology of myocardial infarction. Intech Open,
; 10-17.
Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset kesehatan dasar.
Jakarta, Kementerian Keseharan Republik Indonesia. 2013; 91-92.
Hata J, Kiyohara Y. Epidemiology of stroke and coronary artery disease in Asia. Circ J, 2013; 77:
-1932.
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, et al. Third universal definition of myocardial infarction. Circulation, 2012; 126: 2020-2035.
Anderson JL, Morrow DA. Acute myocardial infarction. N Engl J Med, 2017; 37: 2053-2064.
Reed GW, Rossi J, Cannon CP. Acute myocardial infarction. Lancet, 2017; 389: 197-210.
Kumar A, Cannon CP. Acute coronary syndromes: Diagnosis and management, part I. Mayo Clin proc,
; 84(10): 917-938.
Slavka G, Perkmann T, Haslacher H, Greisenegger S, Marsik C, et al. Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease. Arterioscler Thromb Vasc Biol, 2011; 31(5): 1215-1228.
Syahrir W, Kurniawan LB, Rauf D. Analysis of mean platelet volume as a marker for myocardial infarction and non-myocardial infarction in acute coronary syndrome. Indonesian Journal of Clinical Pathology and Medical Laboratory. 2017; 24(1): 76-80.
Patil KS, Karchi SD. A comparative study of platelet indices in acute coronary syndrome. International
Journal of Contemporary Medical Research, 2017; 4(3): 657-660.
Khalifa KA, Helwa MA, Mohammed MAM. Reticulated platelets in acute coronary syndrome patients.
Menoufia Med J, 2017; 30: 880-886.
Grove EL, Hvas A, Kristensen SD. Immature platelet in patients with acute coronary syndrome, 2009; 101: 151-156.
Dhingra R, Vasan RS. Age as a cardiovascular risk factor. Med Clin North Am, 2012; 96(11): 87-91.
Alvitagala BY, Azra MAF, Kottahachchi DU, Jayasekera MMPT, Wijesinghe RANK. A study of association between platelet volume indices and ST-elevation myocardial infarction. IJC Heart & Vasculature, 2018; 21: 7-10.
Machanda J, Potekar RM, Badiger S, Tiwari A. The study of platelet indices in acute coronary syndromes. Annals of Pathology and Laboratory Medicine. 2015; 2(1): A30-A35.
Muhibbah, Wahid A, Agustina R, Illiandri O. Karakteristik pasien sindrom koroner akut pada pasien
rawat inap ruang Tulip di RSUD Ulin Banjarmasin. Indonesian Journal for Health Science, 2019; 3(1): 6-12.
Chakrabarti S, Morton JS, Davidge ST. Mechanism of estrogen on endothelium: An overview. Canadian Journal of Cardiology, 2013; 13: 1-8.
Guetta V, Cannonll RO. Cardiovascular effects of estrogen and lipid-lowering therapies in postmenopausal women. Circulation, 1996; 93: 1928-1937.
Rosengren A, Wallentin L, Simoons M, Gitt AK, Behar S, et al. Cardiovascular risk factors and clinical
presentation in acute coronary syndromes. Heart, 2005; 91(9): 1141-1147.
Ceponiene I, Zaliaduonyte-Peksiene D, Gustiene O, Tamosiunas A, Zaliunas R. Association of major
cardiovascular risk factors with the development of acute coronary syndrome in Lithuania. Eur Heart J
Suppl, 2014; 16(Suppl A): A80-A83.
Diastutik D. Proporsi karakteristik penyakit jantung koroner pada perokok aktif berdasarkan karakteristik merokok. Jurnal Berkala Epidemiologi, 2016; 4(3): 326-337.
Huang HL, Chen CH, Kung CT, Sung PH, You HL, et al. Clinical utility of mean platelet volume and immature platelet fraction in acute coronary syndrome. Biomed J, 2019; 42(2): 107-115.
Ahamed H, Henry RA, Pai R. Association of mean platelet volume and acute coronary syndrome. Int J
Res Med Sci, 2017; 5(4): 1217-1220.
Pipliwal PS, Singh G, Ishran R, Bansal S. Mean platelet volume and other platelet volume indices in patients with acute myocardial infarction: A case-control study. IOSR-JDMS, 2015; 14(11): 35-38.
Cetin MS, Cetin EHO, Akdi A, Aras D, Topaloglu S, et al. Platelet distribution width and plateletcrit: Novel biomarkers of ST-elevation myocardial infarction in young patients. Kardiologia Polska, 2017; 75 (10): 1005–1012.
Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, et al. Platelet volume indices in
patients with coronary artery disease and acute myocardial infarction: An Indian scenario. J Clin Pathol,
; 59: 146–149.
Ranjith MP, Divya R, Mehta VK, Krishnan MG, KamalRaj R, et al. Significance of platelet volume indices and platelet count in ischaemic heart disease. J Clin Patho, 2009; 62: 830-833.
Daly M. Determinant of platelet count in humans. Haematologica, 2011; 96(1): 10-13.
Al-Obeidi SRH, Ahmedm SH, Obeid FA. Evaluation of platelet indices in patients with acute coronary
syndrome. Muntansiriya Medical Journal, 2013; 12(1): 58-63.
Costa SC, Vinagre CGM, Chacra APM, Azevedo MRA. Platelet indices in patients with acute coronary
syndrome. Journal of Biosciences and Medicines, 2015; 3: 71-76.
Downloads
Submitted
Accepted
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.