Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis

Authors

  • Paulus Budiono Notopuro Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya http://orcid.org/0000-0001-6927-2205
  • Arifoel Hajat Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya
  • Made Putra Sedana Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya

DOI:

https://doi.org/10.24293/ijcpml.v27i2.1621

Keywords:

Disseminated histoplasmosis, immunodeficiency, hemophagocytic syndrome, pancytopenia, splenomegaly

Abstract

Disseminated histoplasmosis is a severe manifestation of fungal infection caused by Histoplasma capsulatum. It usually occurs in a patient with an immunodeficiency state. With the increase of HIV infection and the use of immunosuppressant drugs lately, its prevalence also increases. A case of 43 years old female with prolonged fever, pancytopenia, and massive progressive splenomegaly. The diagnosis of disseminated histoplasmosis and the secondary hemophagocytic syndrome was made based on bone marrow examination that showed increased hemophagocytic processes and multiple
intracytoplasmic H.capsulatum. She had been treated with Itraconazole 200 mg for three months. In the first month's evaluation, her complete blood count improved without any transfusions, and the size of her spleen size decreased. She had been fully recovered after the completion of 3-month treatment.

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Author Biographies

Paulus Budiono Notopuro, Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya

Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya

Arifoel Hajat, Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya

Department of Clinical Pathology, Faculty of Medicine, Airlangga University, Surabaya

Made Putra Sedana, Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya

Department of Internal Medicine, Faculty of Medicine, Airlangga University, Surabaya

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Submitted

2020-01-31

Accepted

2020-03-06

Published

2021-04-15

How to Cite

[1]
Notopuro, P.B., Hajat, A. and Sedana, M.P. 2021. Pancytopenia and Progressive Splenomegaly in Patient with Disseminated Histoplasmosis. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 2 (Apr. 2021), 228–231. DOI:https://doi.org/10.24293/ijcpml.v27i2.1621.

Issue

Section

Case Report