Diagnostic Value of Platelet Indices in Patients with Pulmonary Embolism

Andi Handayani Tanra, Lopa AT, Esa T, Rauf DE

Abstract


Pulmonary embolism is caused by a thrombus that blocks the pulmonary artery. The role of the platelet is mainly related
to the formation of thrombus. This study aimed to determine the diagnostic value of platelet indices in patients with
pulmonary embolism. This study was a retrospective observational research involving 55 patients with and without
pulmonary embolism at the period of January 2014 and June 2019 at Dr. Wahidin Sudirohusodo Central Hospital, Makassar.
The diagnosis of pulmonary embolism was based on CT angiography. Platelet Indices (PI), Mean Platelet Volume (MPV),
Platelet Distribution Width (PDW), and plateletcrit (Pct) were analyzed respectively in two groups. Thirty-one (56.3%)
patients were diagnosed with pulmonary embolism. There was significant difference of MPV and Pct values between
embolism and non-embolism group (9.3±1.5 fL vs. 9.5±0.7 fL, p=0.49) and (0.2±0.1% vs. 0.2±0.1%, p=0.82). Contrastingly,
there was a significant difference in PDW value between the two groups (13.2±4.9 fL vs. 9.9±1.1 fL, p=0.002). Receiver
Operating Characteristics (ROC) analysis showed cut-off value ≥ 10.5 fL of PDW with a sensitivity of 77.4%, a specificity of
75%, Positive Predictive Value (PPV) of 80%, and Negative Predictive Value (NPV) of 72%. Platelet indices (PDW) showed a
good diagnostic value on pulmonary embolism disease with a cut-off value ≥ of 10.5fL.


Keywords


Pulmonary embolism, platelet indices

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DOI: http://dx.doi.org/10.24293/ijcpml.v27i1.1625

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