Diagnostic Value of Platelet Indices in Patients with Pulmonary Embolism

Authors

  • Andi Handayani Tanra Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar
  • Lopa AT Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Tadjuddin Chalid General Hospital, Makassar
  • Esa T Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Dadi General Hospital, Province of South Sulawesi
  • Rauf DE Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Faisal Islamic Hospital, Makassar

DOI:

https://doi.org/10.24293/ijcpml.v27i1.1625

Keywords:

Pulmonary embolism, platelet indices

Abstract

Pulmonary embolism is caused by a thrombus that blocks the pulmonary artery. The role of the platelet is mainly related to the formation of thrombus. This study aimed to determine the diagnostic value of platelet indices in patients with pulmonary embolism. This study was a retrospective observational research involving 55 patients with and without pulmonary embolism at the period of January 2014 and June 2019 at Dr. Wahidin Sudirohusodo Central Hospital, Makassar. The diagnosis of pulmonary embolism was based on CT angiography. Platelet Indices (PI), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), and plateletcrit (Pct) were analyzed respectively in two groups. Thirty-one (56.3%) patients were diagnosed with pulmonary embolism. There was significant difference of MPV and Pct values between embolism and non-embolism group (9.3±1.5 fL vs. 9.5±0.7 fL, p=0.49) and (0.2±0.1% vs. 0.2±0.1%, p=0.82). Contrastingly, there was a significant difference in PDW value between the two groups (13.2±4.9 fL vs. 9.9±1.1 fL, p=0.002). Receiver Operating Characteristics (ROC) analysis showed cut-off value ≥ 10.5 fL of PDW with a sensitivity of 77.4%, a specificity of 75%, Positive Predictive Value (PPV) of 80%, and Negative Predictive Value (NPV) of 72%. Platelet indices (PDW) showed a good diagnostic value on pulmonary embolism disease with a cut-off value ≥ of 10.5fL.

Downloads

Download data is not yet available.

Author Biographies

Andi Handayani Tanra, Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar

Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar

Lopa AT, Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Tadjuddin Chalid General Hospital, Makassar

Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Tadjuddin Chalid General Hospital, Makassar

Esa T, Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Dadi General Hospital, Province of South Sulawesi

Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Dadi General Hospital, Province of South Sulawesi

Rauf DE, Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Faisal Islamic Hospital, Makassar

Department of Clinical Pathology, Faculty Medicine, Hasanuddin University/Dr.Wahidin Sudirohusodo Hospital, Makassar/Faisal Islamic Hospital, Makassar

References

Tarbox A, Swaroop M. Pulmonary embolism. International Journal of Critical Illness and Injury

Science. 2013. Available from: http://dx.doi.org/10.4103/2229-5151.109427. (accessed 12 May, 2019).

Wojcik M, Wojcik J, Skoczynskis K. Evaluation of platelet indexes as potential biomarker of suspected

pulmonary embolism. European Journal Clinical Exp Medicine. 2019. Available from: http://dx.doi.org/

15584/ejcem.2019.2.1. (accessed 12 May, 2019).

Varol E, Icli A, Uysal B, Ozaydin M. Platelet indices in patient with acute pulmonary embolism. Scandinavian Journal of Clinical and Laboratory Investigation. 2011. Available from: http://dx.doi.org/10.3109/00365513.2010.5475596. (accessed 28 May, 2019)

Cevik I, Narci H, Dundar G, Ayrik C, Babus S. Is there a diagnostic value for the platelet indices patient in pulmonary embolism?. Hong Kong Journal of Emergency Medicine. 2017. Available from: http://dx.doi.org/10.1177/1024907917743489. (accessed 16 May, 2019)

Talay F, Ocak T, Alcelik A, Erkuran K, Akkaya A, et al. A new diagnostic marker for acute pulmonary

embolism in Emergency Department: Mean platelet volume. Available from: http://ncbi.nlm.hih.gov.

(accessed 12 June, 2019)

Huang J, Chen Y, Cai Z, Chen P. Diagnostic value of platelet indexes for pulmonary embolism. American Journal of Emergency Medicine. 2015. Available from: http://dx.doi.org/10.1016/j.ajem.2015.02043. (accessed 8 June, 2019)

Chung T, Connor D, Joseph J, Emmett L, Mansbetg R, Peters M. Platelet activation in acute pulmonary

embolism. Journal of Thrombosis and Hemostasis. 2007. Available from: http://dx.doi.org/10.1111/

type of anticoagulant, and the time interval between blood collection and sample processing can produce j.1538-7836.2007.02461.x. (accessed 8 June, 2019).

Moharamzadeh P, Rahman F, Foroughifar S, Shahsavarinia K. Reliability of platelet indices for diagnosing pulmonary embolism; a brief report. Advanced Journal of Emergency Medicine. 2019.

Available from: http://dx.doi.org/10.22114/ajem.V0i0.137. (accessed 18 June, 2019).

Araz O, Albez FS, Ucar EY, Kerget BY, lmaz N, Akgun M. Predictive value of mean platelet volume for

pulmonary embolism recurrence. Lung, 2017; 195(4): 497-502. Available from: http://dx.doi.org/10.1007/

s00408-017-0020-7. (accessed 28 August, 2019).

Hamur H, Kalkan K, Duman H, DurakoÄŸlugil ME, Küçüksu Z, Inci S, et al. Plateletcrit and platelet

distribution width as independent predictors of coronary artery ectasia. KoÅŸuyolu Hear J, 2016; 19(3):

-8. Available from: http://dx.doi.org/10.5578/khj.20979. (accessed 19 August, 2019).

Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia, 2010; 14(1): 28. Available from: http://www.researchgate.net/publication/43248183. (accessed 18 June, 2019).

Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating platelets as mediators of immunity,

inflammation, and thrombosis. Circ Res, 2018; 122(2): 337-51. Available from: http://dx.doi.org/

1161/CIRCRESAHA.117.310795. (accessed 20 August, 2019).

Telo S, Kirkil G, Kaman D, Bulmus FG. Does platelet indices play a role in the distinction of pulmonary

embolism clinical forms?. J Turgut Ozal Med Cent, 2017; 24(3): 287-91. Available from: http://dx.doi.org/10.5455/jtomc.2017.03.046. (accessed 8 August, 2019).

Hilal E, Neslihan Y, Gazi G, Sinan T, Ayfer AZ. Does the mean platelet volume have any importance in patients with acute pulmonary embolism?. Wien Klin Wochenschr, 2013; 125(13-14): 381-5. Available from: http://dx.doi.org/10.1007/s00508-013-0380-9. (accessed 8 August, 2019).

Kostrubiec M, Åabyk A, Pedowska-WÅ‚oszek J, Hrynkiewicz-SzymaÅ„ska A, Pacho S, et al. Mean

platelet volume predicts early death in acute pulmonary embolism. Heart, 2010; 96(6): 460-5.

Available from: http://dx.doi.org/10.1136/hrt.2009. 180489. (accessed 19 August, 2019).

Downloads

Submitted

2020-02-04

Accepted

2020-03-06

Published

2020-12-07

How to Cite

[1]
Tanra, A.H., AT, L., T, E. and DE, R. 2020. Diagnostic Value of Platelet Indices in Patients with Pulmonary Embolism. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 1 (Dec. 2020), 22–26. DOI:https://doi.org/10.24293/ijcpml.v27i1.1625.

Issue

Section

Articles