Analysis of Pre-and Post-operative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Acute Kidney Injury After Coronary Artery Bypass Grafting Surgery

Lonasis Cabuslay, Lopa AT, Wibawa SY, Rauf DE


Acute Kidney Injury (AKI) remains a common complication of post-operative Coronary Artery Bypass Grafting (CABG)
related to high morbidity and mortality. Systemic inflammation has been known as a part of the pathogenesis of acute kidney
injury. This study aimed to analyze the Neutrophil Lymphocyte (N/L) ratio and Platelet Lymphocyte (P/L) ratio in post-operative
AKI. This research was a retrospective study involving 76 patients who underwent CABG surgery in Dr. Wahidin Sudirohusodo
Central Hospital, Makassar, between January 2015 and May 2019. The diagnosis of AKI was based on Kidney Disease Improving
Global Outcomes (KDIGO) 2012 criteria. The N/L ratio and P/L ratio were calculated respectively as a neutrophil count ratio to
lymphocyte count and platelet count to lymphocyte count. Twenty-five (32.9%) patients developed AKI in the first 48 hours of
the post-operative period. There was no difference in pre-operative N/L ratio and the P/L ratio between AKI and non-AKI
groups (p > 0.05). Both ratios increased after surgery and were significantly different between the two groups with higher mean
ratio in non-AKI (16.93±9.16 vs. 21.86±11.13, p=0.040 and 239,24±184,36 vs. 314,49±143,73, p=0.011). Both pre-operative
and post-operative N/L ratio and P/L ratio could not distinguish AKI after CABG.


Coronary artery bypass grafting, acute kidney injury, neutrophil-lymphocyte ratio, platelet lymphocyte ratio

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