Antibiotic Susceptibility Pattern of Extended-Spectrum Beta-Lactamase-Producing Klebsiella Pneumoniae and Escherichia Coli

Authors

  • Erlina Wahyu Elmawati Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Dewi Indah Noviana Pratiwi Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Noor Muthmainah Department of Microbiology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Agung Biworo Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

DOI:

https://doi.org/10.24293/ijcpml.v27i3.1634

Keywords:

Extended-spectrum beta-lactamase, Klebsiella pneumoniae, Escherichia coli, antibiotics susceptibility pattern, intensive care units

Abstract

Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria is a type of resistance that leads to complex management of patients in intensive care due to their resistance to first, second, and third-generation Cephalosporin and monobactam antibiotics. The most ESBL-producing bacteria are found in the family Enterobacteriaceae, especially Klebsiella pneumoniae and Escherichia coli. The purpose of this research was to determine the sensitivity pattern of ESBLproducing bacteria in Intensive Care Units (ICUs) of Ulin Hospital, Banjarmasin, in the period of 2016-2018. This research was a descriptive study with a cross-sectional approach using data from the laboratory medical records of patients with positive ESBL in the ICUs of Ulin Hospital, Banjarmasin, between 2016 and 2018. The research sample was taken by the total sampling method. This research obtained 216 isolates of ESBL-producing bacteria consisting of 155 (71.8%) isolates of Klebsiella pneumoniae and 61 (28.2%) Escherichia coli. It was found that the Cephalosporin antibiotics (Cefazolin, Ceftazidime, Ceftriaxone, and Cefepime) and monobactam antibiotic (Aztreonam) had the lowest sensitivity. Aminoglycoside antibiotics (Amikacin), Carbapenem (Ertapenem and Meropenem), and Tetracycline (Tigesycline) were the most sensitive antibiotics. It was concluded that both Klebsiella pneumoniae and Escherichia coli were the most dominant ESBL-producing bacteria and showed good sensitivity to the Amikacin, Ertapenem, Meropenem, and Tigecycline.

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Author Biographies

Erlina Wahyu Elmawati, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Dewi Indah Noviana Pratiwi, Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Noor Muthmainah, Department of Microbiology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Department of Microbiology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Agung Biworo, Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

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Submitted

2020-02-23

Accepted

2021-01-08

Published

2021-09-21

How to Cite

[1]
Elmawati, E.W., Pratiwi, D.I.N., Muthmainah, N. and Biworo, A. 2021. Antibiotic Susceptibility Pattern of Extended-Spectrum Beta-Lactamase-Producing Klebsiella Pneumoniae and Escherichia Coli. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 3 (Sep. 2021), 282–288. DOI:https://doi.org/10.24293/ijcpml.v27i3.1634.

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