Antibiotic Susceptibility Pattern of Extended-Spectrum Beta-Lactamase-Producing Klebsiella Pneumoniae and Escherichia Coli

Erlina Wahyu Elmawati, Dewi Indah Noviana Pratiwi, Noor Muthmainah, Agung Biworo

Abstract


Extended-Spectrum Beta-Lactamase (ESBL) producing bacteria is a type of resistance that leads to complex management of patients in intensive care due to their resistance to first, second, and third-generation Cephalosporin and monobactam antibiotics. The most ESBL-producing bacteria are found in the family Enterobacteriaceae, especially Klebsiella pneumoniae and Escherichia coli. The purpose of this research was to determine the sensitivity pattern of ESBLproducing bacteria in Intensive Care Units (ICUs) of Ulin Hospital, Banjarmasin, in the period of 2016-2018. This research was a descriptive study with a cross-sectional approach using data from the laboratory medical records of patients with positive ESBL in the ICUs of Ulin Hospital, Banjarmasin, between 2016 and 2018. The research sample was taken by the total sampling method. This research obtained 216 isolates of ESBL-producing bacteria consisting of 155 (71.8%) isolates of Klebsiella pneumoniae and 61 (28.2%) Escherichia coli. It was found that the Cephalosporin antibiotics (Cefazolin, Ceftazidime, Ceftriaxone, and Cefepime) and monobactam antibiotic (Aztreonam) had the lowest sensitivity. Aminoglycoside antibiotics (Amikacin), Carbapenem (Ertapenem and Meropenem), and Tetracycline (Tigesycline) were the most sensitive antibiotics. It was concluded that both Klebsiella pneumoniae and Escherichia coli were the most dominant ESBL-producing bacteria and showed good sensitivity to the Amikacin, Ertapenem, Meropenem, and Tigecycline.


Keywords


Extended-spectrum beta-lactamase, Klebsiella pneumoniae, Escherichia coli, antibiotics susceptibility pattern, intensive care units

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References


Khan HA, Baig FK, Mehboob R. Nosocomial infections:

epidemiology, prevention, control dan surveillance.

Asian Pac J Trop Biomed, 2017; 7(5): 478-9.

Taslim, Emilzon, Tinni T. Maskoen. Pola kuman

terbanyak sebagai agen penyebab infeksi di intensive

care unit pada beberapa rumah sakit di Indonesia.

Perdatin, 2016; 34: 57-8.

Kambuno, Norma Tiku, Dicky Fanggidae. Identifikasi

bakteri Gram-negatif galur extended-spectrum

beta-lactamase pada ruang NICU RSUD Prof. DR. W. Z.

Johannes Kupang. JIK, 2017; 15: 334-341.

Tsai MH, Chu SM, Hsu JF, Lien R, Huang HR, et al. Risk

factors and outcomes for multidrug-resistant

Gram-negative bacteremia in the NICU. Pediatrics,

; 133(2): 324-6.

Folgore L, Bielicki J, Heath PT, Sharland M.

Antimicrobial-resistant Gram-negative infections in

neonates: Burden of disease and challenges in

treatment. Curr Opin Infect Dis, 2017; 30: 2-3.

Anggraini D, Uswatun HS, Maya S, Fauzia AD, Dino I,

Ruza PR. Prevalensi dan pola sensitivitas

enterobacteriaceae penghasil ESBL di RSUD Arifin

Achmad Pekanbaru. JKB, 2017; 30(1): 48.

Muhajir, Ahmad Siddiq, Priyo Budi Purwono,

Samsriyaningsih Handayani. Gambaran terapi luaran

infeksi saluran kemih oleh bakteri penghasil

extended- spectrum beta-lactamase pada anak di

RSUD Dr. Soetomo Surabaya. Sari Pediatri, 2016; 18(2):

-4.

Kiddie A, Assawatheptawee K, Na-udom A,

Boonsawang P. Risk factor for extended-spectrum

beta-lactamase-producing Enterobacteriaceae

carriage inpatient admitted to intensive care unit in a

tertiary care hospital in Thailand. MDR, 2019: 1-3.

Bindu MH, Kasturi T, Reddy M, Indu K. Prevalence of

ESBL Production in Escherichia coli and Klebsiella spp.

from different clinical samples–A study in a teaching

hospital in Telangana, India. IJCMAS, 2015; 4(3): 236-7.

Padmini N, Ajilda AAK, Sivakumar N, Selvakumar G.

Extended-spectrum beta-lactamase-producing

Escherichia coli and Klebsiella pneumoniae: Critical

tools for antibiotic resistance pattern. J Basic

Microbiol, 2017; 57: 464-5.

Sinanjung K, Aman AT, Nirwati H. Proporsi

Klebsiella pneumoniae isolat klinik penghasil

Extended-Spectrum Beta Lactamase (ESBL) beserta

pola kepekaannya terhadap antibiotika di RSUP Dr.

Soeradji Tirtonegoro Klaten. Yogyakarta, Fakultas

Kedokteran Universitas Gadjah Mada, 2019. (Tesis).

Luyt CE, Hékimian G, Koulenti D, Chastre J. Microbial

cause of ICU-acquired pneumonia: Hospital-acquired

pneumonia versus ventilator-associated pneumonia.

Curr Opin Crit Care, 2018; 24(5): 333-334.

Sansom D, Merchant AT, Wara-Aswapati N,

Ruaisungnoen W, Pitiphat W. Oral health and

ventilator-associated pneumonia among critically ill

patients: A prospective study. Oral Dis, 2016; 22(7):

-14.

European Centre for Disease Prevention and Control.

Introduction to the annual epidemiological report for

In: ECDC. Annual epidemiological report for

Stockholm, ECDC, 2017. Available from:

https://ecdc.europa.eu/en/publications-data/

healthcare-associated-infections-acquired-intensive

-care-units-annual (accessed 9 November, 2018).

Carrol KC, Hobden JA, Mietzner T, Miller S. Jawetz,

th Melnick, and Adelberg's Medical Microbiology. 27

Ed., New York, McGraw-Hill Education, 2016; 383-7.

Sah SK, Hemalatha S. Extended-Spectrum

Beta-Lactamase (ESBL) mechanism of antibiotic

resistance and epidemiology. Int. J PharmTech

Research, 2015; 7(2): 304.

Fauziyah, Siti, Maksum Radji, Nurgani A. Hubungan

penggunaan antibiotika pada terapi empiris dengan

kepekaan bakteri di ICU RSUP Fatmawati Jakarta. JFI,

; 5(3): 158.




DOI: http://dx.doi.org/10.24293/ijcpml.v27i3.1634

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