Interleukin-34 and Disease Activity in Systemic Lupus Erythematosus Patients

Rizki Luly Ya Fatwa Pulungan, Ratna Akbari Ganie, Zuhrial Zubir

Abstract


Systemic Lupus Erythematosus (SLE) is characterized by exacerbation and remission, which needs close monitoring of
the disease activity. Systemic lupus erythematosus disease activity can be determined by the SLE Disease Activity Index
(SLEDAI) score. Evaluation of the disease activity is essential to be a guidance for treatment. Interleukin-34 (IL-34) is related
to the pathogenesis of SLE. Serum IL-34 can be a candidate marker to evaluate SLE disease activity, and it is correlated with
the SLEDAI score. This study aimed to determine the correlation between IL-34 level and disease activity in SLE patients
based on the SLEDAI (Mex-SLEDAI) score. An observational analytical study with a cross-sectional design was carried out in
six months (June-November 2019) in 27 SLE patients in the Department of Internal Medicine, Faculty of Medicine, Sumatera
Utara University/Adam Malik General Hospital, Medan. Systemic lupus erythematosus disease activity was measured based
on the Mex-SLEDAI score. Serum and urine were collected to obtain the Mex-SLEDAI score and IL-34 level. IL-34 level was
measured in all subjects by using Enzyme-Linked Immunosorbent Assay (ELISA). Spearman correlation test was used to
determine the correlation between IL-34 level and disease activity in SLE patients based on the SLEDAI (Mex-SLEDAI) score.
There was a significant correlation between IL-34 level and disease activity in SLE patients based on SLEDAI (Mex-SLEDAI)
score (r=0.965, p < 0.001). Further studies were needed with a sample of SLE patients in a balanced proportion based on
their disease activity to obtain representative IL-34 levels in SLE patients based on their disease activity.


Keywords


Systemic lupus erythematosus, interleukin-34, SLEDAI, Mex-SLEDAI

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DOI: http://dx.doi.org/10.24293/ijcpml.v27i2.1636

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