Cross-Reaction Antibody Test between SARS-CoV-2 and Dengue Hemorrhagic Fever in Indonesia

Danny Luhulima, Tri Soetowo, Ria Amelia


Coronaviruses are a family of viruses that cause illness from the common cold to severe diseases such as Severe Acute
Respiratory Syndrome (SARS-CoV). In December 2019, forty new cases of pneumonia of unknown etiology have been
reported in Wuhan, China. The disease resembles Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and has
been subsequently named the 2019-novel Coronavirus Disease (COVID-19). The antibody test is a blood test that provides
quantitative and qualitative detection of IgG and IgM antibodies against the SARS-CoV-2. Reported a male, 43-year old
suffering from DHF, but the results of an IgG and IgM rapid test were COVID-19 reactive. Also, reviewed rapid tests for
COVID-19 and the results showed that only IgG was reactive. This explained that the patient already had SARS Cov-2
antibodies but was not suffering from the disease. The rapid test COVID-19 IgM result was deemed to be a false positive.


COVID-19, dengue hemorrhagic fever, cross-reaction

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