Correlation between Adiponectin and Triglyceride Levels in Pregnancy with and without Gestational Diabetes Mellitus

I Nyoman Gde Sudana, Windarwati Windarwati, Budi Mulyono


Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty acids so that triglyceride synthesis decreases in pregnancy. This study was conducted to determine the relationship between adiponectin and triglyceride levels in pregnancy, especially in a pregnant female with and without gestational diabetes mellitus. This observational cross-sectional study was conducted by measuring the levels of adiponectin and triglycerides in pregnancy, with and without gestational diabetes mellitus. Researchers proved by analyzing 75 subjects, 24-28 weeks pregnant females who were examined at the primary health center and Dr. Sardjito Hospital, Yogyakarta. Adiponectin levels have a moderate negative correlation with triglycerides in pregnant females (r= -0.420 and p=0.002), a strong negative correlation with GDM (r = -0.680 and p=0.001), and moderate negative correlation (r= -0.455, and p=0.022) with those without GDM. Based on this research can be concluded that adiponectin has a moderate negative correlation with triglycerides in pregnancy, a strong negative correlation in pregnant females with gestational diabetes mellitus, and a moderate negative correlation in those without gestational diabetes.


Gestational diabetes mellitus, adiponectin, triglycerides

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Rahayu A, Rodiani. Indonesian clinical practice

guidelines for diabetes in pregnancy. JAFES, 2016;

: 1–6.

Rahmawati F, Natosba J, Jaji. Intermediate metabolism

in normal pregnancy and in gestational diabetes.

Diabetes Metab Res Rev, 2016; 19: 259–270.

Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T,

Christiansen M. Adiponectin and leptin as first trimester

markers for gestational diabetes mellitus: A cohort

study. Clin Chem Lab Med, 2017; 0427: 1-6.

Pala HG, Ozalp Y, Yenner AS, Gercekliolu G, Uysal S,

Onvural A. Adiponectin levels in gestational diabetes

mellitus and in pregnant women without glucose

intolerance. Adv Clin Exp Med, 2015; 24, 85-92.

Leung K, Draper JT, Boeras C, Min SY, Rojas-Rodriguez R,

et al. Human adipose tissue expansion in pregnancy is

impaired in gestational diabetes mellitus. Diabetologia,

; 58(9): 2106–14.

Bharathi KR, Vijayalakshmi S, Shrunga RP. Original

research article a study of lipid parameters among GDM

and non-GDM pregnant women: A hospital based

study. Int J Reprod Contracept Obstet Gynecol, 2017;

(12): 5488–90.

Chatterjee VKK, Wareham NJ, Rahilly SO. Elevated

plasma adiponectin in humans with genetically defective

insulin receptors. J Clin Endocrinol Metab, 2017; 91:


Brand-Miller JC, Thomas M, Swan V, Ahmad ZI, Petocz P,

Colagiuri, S. Physiological Validation of the Concept of

Glycemic Load in Lean Young Adults. Int J Nutr, 2018;

(9): 2728–2732.

Bhavadharini B, Uma R, Saravanan P, Mohan V.

Screening and diagnosis of gestational diabetes

mellitus–relevance to low and middle income

countries. J Clin Endocrinol Diabetes, 2016; 2(1): 13.

Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers

MH. The pathophysiology of gestational diabetes

mellitus. Int J Mol Sci, 2018; 19: 1–21.

Hernandez TL, Pelt RE. Van, Anderson MA, Reece MS,

Reynolds RM, et al. Women with gestational diabetes

mellitus randomized to a higher–complex

carbohydrate/low-fat diet manifest lower adipose

tissue insulin resistance, inflammation, glucose, and free

fatty acids: A pilot study. Diabetes Care, 2016; 39: 39–42.

Ott R, Stupin JH, Melchlor K, Schellong K, Thomas Ziska

T, et al. Alteration of adiponectin gene expression and

dna methylation in adipose tissues and blood cells

are associated with gestational diabetes and neonatal

outcome. Clinical Epigenets, 2018; 10: 131-142.

Stewart A, Malhotra A. Gestational diabetes and the

neonate: Challenges and solutions. Res Rep Neonatol,

; 31–39.

Ashcroft FM, Rohm M, Clark A, Brereton MF. Is type 2

diabetes a glycogen storage disease of pancreatic

β-cells?. Cell Metab, 2017; 26(1): 17–23.



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