Correlation between Adiponectin and Triglyceride Levels in Pregnancy with and without Gestational Diabetes Mellitus

Authors

  • I Nyoman Gde Sudana Sanglah General Hospital Denpasar, Bali
  • Windarwati Windarwati Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta
  • Budi Mulyono Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta

DOI:

https://doi.org/10.24293/ijcpml.v27i3.1697

Keywords:

Gestational diabetes mellitus, adiponectin, triglycerides

Abstract

Gestational Diabetes Mellitus (GDM) is glucose intolerance during pregnancy. Adiponectin causes a decrease in glucose transporter 4 translocation, which reduces glucose uptake due to downstream insulin signal delivery and decreases non-esterified fatty acids so that triglyceride synthesis decreases in pregnancy. This study was conducted to determine the relationship between adiponectin and triglyceride levels in pregnancy, especially in a pregnant female with and without gestational diabetes mellitus. This observational cross-sectional study was conducted by measuring the levels of adiponectin and triglycerides in pregnancy, with and without gestational diabetes mellitus. Researchers proved by analyzing 75 subjects, 24-28 weeks pregnant females who were examined at the primary health center and Dr. Sardjito Hospital, Yogyakarta. Adiponectin levels have a moderate negative correlation with triglycerides in pregnant females (r= -0.420 and p=0.002), a strong negative correlation with GDM (r = -0.680 and p=0.001), and moderate negative correlation (r= -0.455, and p=0.022) with those without GDM. Based on this research can be concluded that adiponectin has a moderate negative correlation with triglycerides in pregnancy, a strong negative correlation in pregnant females with gestational diabetes mellitus, and a moderate negative correlation in those without gestational diabetes.

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Author Biographies

I Nyoman Gde Sudana, Sanglah General Hospital Denpasar, Bali

Sanglah General Hospital Denpasar, Bali

Windarwati Windarwati, Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta

Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta

Budi Mulyono, Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta

Department of Clinical Pathology, Faculty of Medicine, Gadjah Mada University/Dr. Sardjito Hospital, Yogyakarta

References

Rahayu A, Rodiani. Indonesian clinical practice guidelines for diabetes in pregnancy. JAFES, 2016;

: 1–6.

Rahmawati F, Natosba J, Jaji. Intermediate metabolism in normal pregnancy and in gestational diabetes. Diabetes Metab Res Rev, 2016; 19: 259–270. 3. Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T, Christiansen M. Adiponectin and leptin as first trimester markers for gestational diabetes mellitus: A cohort study. Clin Chem Lab Med, 2017; 0427: 1-6.

Pala HG, Ozalp Y, Yenner AS, Gercekliolu G, Uysal S, Onvural A. Adiponectin levels in gestational diabetes mellitus and in pregnant women without glucose intolerance. Adv Clin Exp Med, 2015; 24, 85-92.

Leung K, Draper JT, Boeras C, Min SY, Rojas-Rodriguez R, et al. Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia, 2015; 58(9): 2106–14.

Bharathi KR, Vijayalakshmi S, Shrunga RP. Original research article a study of lipid parameters among GDM and non-GDM pregnant women: A hospital based study. Int J Reprod Contracept Obstet Gynecol, 2017; 6(12): 5488–90.

Chatterjee VKK, Wareham NJ, Rahilly SO. Elevated plasma adiponectin in humans with genetically defective insulin receptors. J Clin Endocrinol Metab, 2017; 91: 3219–23.

Brand-Miller JC, Thomas M, Swan V, Ahmad ZI, Petocz P, Colagiuri, S. Physiological Validation of the Concept of Glycemic Load in Lean Young Adults. Int J Nutr, 2018; 133(9): 2728–2732.

Bhavadharini B, Uma R, Saravanan P, Mohan V. Screening and diagnosis of gestational diabetes

mellitus–relevance to low and middle income countries. J Clin Endocrinol Diabetes, 2016; 2(1): 13.

Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes

mellitus. Int J Mol Sci, 2018; 19: 1–21.

Hernandez TL, Pelt RE. Van, Anderson MA, Reece MS, Reynolds RM, et al. Women with gestational diabetes mellitus randomized to a higher–complex carbohydrate/low-fat diet manifest lower adipose

tissue insulin resistance, inflammation, glucose, and free fatty acids: A pilot study. Diabetes Care, 2016; 39: 39–42.

Ott R, Stupin JH, Melchlor K, Schellong K, Thomas Ziska T, et al. Alteration of adiponectin gene expression and dna methylation in adipose tissues and blood cells are associated with gestational diabetes and neonatal outcome. Clinical Epigenets, 2018; 10: 131-142.

Stewart A, Malhotra A. Gestational diabetes and the neonate: Challenges and solutions. Res Rep Neonatol, 2015; 31–39.

Ashcroft FM, Rohm M, Clark A, Brereton MF. Is type 2 diabetes a glycogen storage disease of pancreatic β-cells?. Cell Metab, 2017; 26(1): 17–23.

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Submitted

2020-09-29

Accepted

2021-02-01

Published

2021-09-21

How to Cite

[1]
Sudana, I.N.G., Windarwati, W. and Mulyono, B. 2021. Correlation between Adiponectin and Triglyceride Levels in Pregnancy with and without Gestational Diabetes Mellitus. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 3 (Sep. 2021), 313–319. DOI:https://doi.org/10.24293/ijcpml.v27i3.1697.

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