Correlation between Serum hs-CRP and Magnesium Ion with Osteocalcin in Acute Leukemia Patients
DOI:
https://doi.org/10.24293/ijcpml.v27i3.1700Keywords:
Acute leukemia, C-reactive protein, osteocalcin, ion magnesiumAbstract
Acute leukemia is a proliferation of immature cells in the bone marrow that affects peripheral blood or other organs. Inflammation has a vital role in cancer pathophysiology. Inflammation in leukemia occurs through two mechanisms: intrinsic and extrinsic. Magnesium deficiency leads to inflammation in acute leukemia patients. Manifestation of inflammation in acute leukemia are abnormalities in musculoskeletal systems such as osteopenia, osteoporosis, osteonecrosis, and pathological fractures. Increased inflammation in the bone remodeling process increases osteoclast (OC) regulation and decreases osteoblast (OB) activity resulting in reduced osteocalcin (OCN) production. Osteocalcin, also known as gamma-carboxy glutamic acid-containing protein or bone Gla-protein, is a small, non-collagen protein associated with the bone matrix. Osteocalcin is known as bone formation. This study aimed to analyze the correlation between hs-CRP, ion Mg and serum OCN levels in acute leukemia. A cross-sectional observational analytic study in acute leukemia subjects was conducted at Clinical Pathology Installation of Dr. Moewardi Hospital. Surakarta from August to September 2020. Normality test of Shapiro-Wilk was used to determine data distribution, Pearson correlation test was used to analyze the correlation strength between variables. From a total of 35 subjects, there was a significant negative correlation between hs-CRP and serum OCN in acute leukemia (r= -0.46; p=0.06), but no correlation was found between Mg ion and serum OCN in acute leukemia patients (r=0.09; p=0.957). The mean of hs-CRP, Mg ion, and OCN was 2.95±4.95 mg/dL, 0.49±0.05 mmol/L, and 16.32±19.46 ng/mL, respectively. Advanced research with chronic leukemia population and other variants as needed.
Downloads
References
Tebbi CK. Etiology of acute leukemia: A review. Cancers, 2021; 13: 2256.
Yaswir R, Wahid I, Rahmadin B. Profil penderita leukemia mieloblastik akut di bagian penyakit dalam
RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 2017; 6(3): 495-501.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, et al. Global cancer statistics 2018: GLOBOCAN
estimated of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2018; 68: 394-424.
Chen L, Deng H, Cui H, Fang J, Zuo Z, et al. Inflammatory responses and inflammation-associated
diseases in organs. Oncotarget, 2018; 6(6): 7204-7218.
Craver BM, Alaoui KE, Scherber RM, Fleischman AG. The critical role of inflammation in the pathogenesis and progression of myeloid malignancies. Cancers, 2018; 10(4): 104.
Sproston NR, Ashworth JJ. Role of C-reactive protein at sites of inflammation and infection. Front. Immunol, 2018; 9: 754.
Fatahi S, Ghaidi E, Mousavi SM, Bawadi H, Rahmani J, et al. The association between osteocalcin and
C-reactive protein; a relation of bone with inflammation: A systematic review and meta-analysis. Hom Metab Res, 2019; 2019(51): 353-361.
Donmez AD, Isik P, Cetinkaya S, Yarali N. Bone loss in pediatric survivors of acute lymphoblastic leukemia. Eurasian J Med, 2019; 51(1): 38-41.
Yang J, Liu Z, He J, Yang J, Lin P, et al. C-reactive protein promotes bone destruction in human myeloma through the CD32-p38MAPK twist axis. Sci Signal, 2018; 10(509): 1-21. Available at: https://www.ncbi. nlm.nih.gov/pmc/articles/PMC5827954/pdf/nihms944048.pdf (accessed 17 August, 2020).
Dahlan MS. Statistik untuk kedokteran dan kesehatan. Epidemiologi Indonesia, Ed VI., Jakarta, Salemba Medika, 2017; 223-244.
Ahmad S, Kifayatullah Shah AK, Hussain H, Haq AU, Ullah A, et al. The prevalence of acute leukemia and chronic forms of leukemia in various regions of Khyber Pakhtunkhwa, Pakistan: Needs much more to be done. Bangladesh Journal of Medical Science, 2019; 18(2): 222-227.
American Cancer Society. Acute lymphocytic leukemia early detection, diagnosis, and types. 2019. Available at: https://www.cancer.org/content/dam/CRC/PDF/Public/8671.00.pdf (accessed 17 August, 2020).
Liem EF, Mantik M, Rampeang N, Hubungan kadar hemoglobin dan tercapainya remisi pada anak penderita leukemia akut. JMR, 2019; 1(3): 1-7.
Wang F, Lv H, Zhao B, Zhou L, Wang S, et al. Iron and leukemia: New insights for future treatments. Journal of Experimental & Clinical Cancer Research, 2019; 38: 406.
Perez JCJ, Arellano GG, Garza LH, Rivera LJM, Almaguer DG. Revisiting the complete blood count
and clinical findings at diagnosis of childhood acute lymphoblastic leukemia: 10-years experience at a
single center. Hematology Transfusion and Cell Therapy, 2018; 41: 47-61.
El-Shafey A, Amer SM, Allam MG, El-Alfy MS. Clinical chemistry studies in Egyptian children with acute
lymphoid and myeloid leukemia. AASCIT, 2017; 3(2): 10-17.
Abdalla AA, Akasha R. Liver enzyme, urea and creatinine among acute lymphocytic leukemia in
Sudanese patients. Journal of Medical and Biological Science Research, 2018; 4(2): 72-75.
Salman AF, Ali KF, Alwan AF. Evaluation of electrolytes in adult patients with acute leukemia before and after chemotherapy. Baghdad Science Journal, 2013; 10(2): 2013.
Tamsil FF. Analisis kadar kreatinin ada anak dengan leukemia limfoblastik akut di pusat kanker anak Estella BLU RSUP Prof Dr. RD Kandau. ECL, 2014; 2(1): 2014.
Gu P, Liu Y, Ding Q. Correlation between osteocalcin and visceral fat area in overweight and obese male population. Int J Clin Exp Med, 2017; 10: 6980-6986.
Rao SS, HU Y, Shie PL, Cao J, Wang ZX. Omentin-1 prevents inflammation-induced osteoporosis by
downregulating the pro-inflammatory cytokines. Springer Nature, 2018; 6-9.
Nielsen FH. Magnesium deficiency and increased inflammation: Current perspectives. Journal of
Inflammation Research, 2018; 11: 25-34.
Downloads
Submitted
Accepted
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
