Relationship between Atherogenic Index of Plasma with HbA1c Levels in Type 2 Diabetes Mellitus Patients
DOI:
https://doi.org/10.24293/ijcpml.v28i1.1743Keywords:
Atherogenic index of plasma, HbA1c, HDL cholesterol, type 2 diabetes mellitus, triglycerideAbstract
Type 2 Diabetes Mellitus (T2DM) is a global health problem due to an increasing prevalence and incidence. HbA1c as a parameter for glycemic control is still above the desired target of 7%. Atherogenic Index of Plasma (AIP) is predicted to be an indicator of cardiovascular disease risk in T2DM. Dyslipidemia in T2DM patients showed a result of increased triglyceride and decreased HDL cholesterol levels. This study aimed to determine the relationship between HbA1c and AIP, triglycerides, and HDL cholesterol in T2DM patients. An analytical observational study using a cross-sectional method on 74 DMT2 patients who underwent HbA1c and lipid profile examinations in January-March 2020. Atherogenic index of plasma was calculated by the logarithmic equation (triglycerides/HDL cholesterol). Data were analyzed by SPSS 25.0. The relationship between HbA1c with AIP, triglycerides, and HDL cholesterol using the Pearson correlation test. Atherogenic index of plasma (0.25±0.25) and triglycerides (211.92±146.09 mg/dL) were found to be higher in the poor glycemic control group (HbA1c
> 7%) than AIP (-0.04±0.20) and triglycerides (108.96±38.96 mg/dL) in the good glycemic control group (p < 0.05). HDL cholesterol (40.08±12.64 mg/dL) was found to be higher in the poor glycemic control group than HDL cholesterol (52.28±18.12 mg/dL) in the good glycemic control group (p < 0.05). There was a significant positive correlation between HbA1c and AIP (r=0.411, p=0.000), HbA1c with triglycerides (r=0.418, p=0.000), and a significant negative correlation between HbA1c and HDL cholesterol (r=-0.233, p=0.046). Insulin resistance can cause lipid metabolism disorders, inflammation, oxidative stress, and coagulation disorders. Maintaining glycemic control and lipid control plays an important role in preventing diabetes complications. There is a significant positive correlation between HbA1c and AIP, HbA1c and triglycerides, and a significant negative correlation between HbA1c and total cholesterol in T2DM patients.
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References
Garcia UG, Vicente AB, Jebari S, Sebal AL, Siddiqi H, et al. Pathophysiology of type 2 diabetes mellitus.
International Journal of Molecular Sciences, 2020; 21: 1-34.
Decroli, E. Diabetes melitus tipe 2. Padang, Pusat Penerbitan Bagian Ilmu Penyakit Dalam Fakultas
Kedokteran Universitas Andalas, 2019; 10-20.
Soelistijo SA, Novida H, Rudijanto A, Soewondo P, Suastika K, et al. Konsensus pengelolaan dan
pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta, PB Perkeni, 2015; 5-20.
Naqvi S, Naveed S, Ali Z, Ahmad SM, Khan RA, et al. Correlation between glycated hemoglobin and
triglyceride level in type 2 diabetes mellitus. Cureus, 2017; 9(6): 1-8.
Evidencio. Atherogenic index plasma. 2020. Available f r o m : h t t p s : / / w w w . e v i d e n c i o . c o m / m o d e l s /show/1141 (accessed January 2, 2020).
Prasad PS, Ganesh V. Correlation of HbA1c with atherogenic index of plasma and endothelial
dysfunction in type 2 diabetic subjects. International Journal of Clinical Biochemistry and Research, 2018; 5(4): 578-582.
Palem SP, Abraham P. Atherogenic index of plasma an indicator for predicting cardiovascular risk in addition to endothelial dysfunction in type 2 diabetic subject. Journal of Clinical and Diagnostic Research, 2018; 12(6): 21-24.
Panjeta E, Jadrić R, Panjeta M, Ćorić J, Dervišević P. Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus. Journal of Health Sciences, 2018; 8(2): 110-116.
Anjankar AP, Kale AB, Sharma PL. Correlation between HbA1c and atherogenic index in type 2 diabetic
patients. International Journal of Current Advanced Reasearch, 2018; 7: 14789-14793.
ADA. American Association Diabetes. 2019. Available from: https://www.diabetes.org/a1c (accessed
January 2, 2020).
Soelistijo SA, Lindarto G, Decroli E, Permana H, Sucipto KW, et al. Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia. Jakarta, PB Perkeni, 2019; 5-10.
Betaubun AM, Bahrun U, Pakasi R. Indeks aterogenik plasma di penyakit diabetes melitus tipe 2. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2015; 22(1): 82-86.
Lestari AA, Shanti DGD. Diktat praktikum kimia klinik 2. Denpasar, Bagian Patologi Klinik Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Udayana, 2017; 38-40.
Ratnasari AD, Indranila I, Retnoningrum D. Hubungan antara HbA1c dengan kadar HDL pada pasien
diabetes melitus tipe 2. Jurnal Kedokteran Diponegoro, 2017; 6(2): 141-147.
Erwinanto, Santoso A, Putranto JNE, Tedjasukmana P, Sukmawan R, et al. Panduan tata laksana dislipidemia. Jakarta, PERKI, 2017; 6-20.
Aman AM, Soewondo P, Soelistijo SA, Arsana PM, Wismandari, et al. Pedoman pengelolaan dislipidemia di Indonesia. Jakarta, PB Perkeni, 2019; 5-20.
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