The Relationship between Platelet to Lymphocyte Ratio and Platelet Indices with Disease Severity Level of Systemic Lupus Erythematosus

Purbosari Lisnaedy, Umi Solekhah Intansari

Abstract


Systemic Lupus Erythematosus (SLE) is an episodic, chronic autoimmune inflammatory disease characterized by remission and flare phases. Laboratory parameters required to assess the severity of disease activity in SLE include platelet count and platelet indices. Several studies regarding the Platelet to Lymphocyte Ratio (PLR) and platelet indices on the severity of SLE patients remain inconsistent. This study aimed to evaluate the relationship between PLR value and platelet index with the degree of disease severity in SLE patients. This study used a retrospective analytic observational design in SLE patients from January 2016 to December 2019 at Dr. Sardjito Central Hospital. Disease severity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score. Platelet to Lymphocyte Ratio (PLR) values and platelet indices were measured with a hematology analyzer. The data were analyzed using correlation, bivariate, multiple regression tests, and the ROC curve to determine the PLR cut-off. There were 55 SLE patients with high activity (SLEDAI 11-19; n=30(54,54%)) and very high activity (SLEDAI 20; n=25(45.45%)). There was a significant correlation (p <0.05) between the PLR value, platelet count, plateletcrit, and Mean Platelet Volume (MPV) with SLEDAI scores (p <0.05), but only the MPV variable was significant as an independent variable (p=0.0357). In the ROC curve, a cut-off PLR value of 124 was obtained with a sensitivity of 68.0%, specificity of 66.7%, likelihood ratio=2.04 (AUC=0.659 with p-value=0.035) to detect very high disease activity. Based on the PLR value, platelet count and plateletcrit negatively correlated with SLEDAI score but were related to the very high degree of thrombocytopenia in disease activity. The MPV value reflected the high platelet turnover, which had a positive correlation with the SLEDAI score. Patients with a PLR value ≤124 were 2.04 times more likely to have a SLEDAI score of 20, indicating potential use as a predictor of disease activity. The PLR value and platelet indices were significantly related to the degree of SLE activity.

Keywords


Platelet to lymphocyte ratio, platelet indices, SLEDAI score, systemic lupus erythematosus

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References


Gao MZ, Huang YL, Wu XD, Xu QW, Ji R, et al. Red

blood cell distribution width and neutrophil to

lymphocyte ratio are correlated with disease activity of

dermatomyositis and polymyositis. J. Clin. Lab.

Analysis, 2018; 32(1): 1-4.

Qin B, Ma N, Tang Q, Wei T, Yang M, et al. Neutrophil

to lymphocyte ratio (NLR) and platelet to lymphocyte

ratio (PLR) were useful markers in assessment of

inflammatory response and disease activity in SLE

patients. Modern Rheumatol, 2016; 26(3): 372-376,

Saleh AM, Kurniati N, Syarif BH. Penilaian aktivitas

penyakit lupus eritematosus sistemik dengan skor

SLEDAI di Departemen Ilmu Kesehatan Anak RSCM.

Sari Pediatri, 2014; 16(4): 292-298.

Dewi SR, Sukorini U, Intansari US. Analisis Indeks

trombosit pada pasien infeksi dengue. Yogyakarta, FK

UGM, 2015; 434 (1): 012312.

Taggara NT. Analisis Indeks trombosit dan rasio

trombosit limfosit sebagai penanda inflamasi

glomerulus pada penderita hipertensi berbagai

derajat. Med. Art, 2019; 1(2): 7-14.

Zian Z, Maamar M, Aouni M, El Barakat A, Naima

Ghailani Nourouti, et al. Immunological and clinical

characteristics of systemic lupus erythematosus: A

series from Morocco. BioMed Res. Int, 2018; 2018:

Article ID 3139404.

Budak YU, Polat M, Huysal K. The use of platelet

indices, plateletcrit, mean platelet volume and platelet

distribution width in emergency non-traumatic

abdominal surgery: A systematic review. Biochem.

Med, 2016; 26(2): 178-193.




DOI: http://dx.doi.org/10.24293/ijcpml.v27i3.1763

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