Hematology and Iron Status Evaluation Based on Donation Characteristics in Dr. Sardjito Hospital, Yogyakarta

Fuad Anshori, Tri Ratnaningsih, Teguh Triyono


Blood donation will reduce iron storage in the body. A high frequency of donations and short interval inter-donations may increase the risk of iron deficiency. In Indonesia, detection of iron deficiency in blood donors is not a routine procedure. Therefore, the comparison of hematology and iron status based on donor characteristics is not widely known. For a month, this study was a cross-sectional study conducted at the Blood Transfusion Service Unit, Dr. Sardjito Hospital. Subjects were routine blood donors who met the criteria for donor selection; however, subjects were excluded if the CRP level was > 10 g/L and had a history of iron supplementation. Subjects were divided based on donation frequency and blood donation interval. The Kruskal-Wallis test was used to compare variables among groups with a statistical significance of p < 0.05. This study involved 145 subjects who met the criteria. Blood donations more than 20 times showed the lowest ferritin levels and iron saturation (16.9 ng/mL and 15.08%). Ferritin levels were also increased in line with the donation interval (35.5 ng/mL; 75.3 ng/mL; 92.7 ng/mL every three months). However, the hematological parameters and iron saturation did not differ significantly based on the donation interval. Hematological parameters are easy and fast procedures but have limitations in the early detection of iron deficiency. Serum ferritin has higher specificity, but its level is affected by inflammatory conditions. Ferritin levels were consistently at the lowest level in the subjects with the highest risk of iron deficiency compared to hematologic and iron saturation parameters.


Iron deficiency, blood donation, hematology, iron status

Full Text:



World Health Organization. Report on gender

distribution of blood donors by country. WHO Global

Database on Blood Safety, 2016; 2-5.

Cable RG, Brambilla D, Glynn SA, Kleinman S, Mast AE,

et al. Effect of iron supplementation on iron stores and

total body iron after whole blood donation.

Transfusion, 2016; 56(8): 2005-12.

Kiss JE, Birch RJ, Steele WR, Wright DJ, Cable RG.

Quantification of body iron and iron absorption in the

REDS-II Donor Iron Status Evaluation (RISE) study.

Transfusion, 2017; 57(7): 1656–64.

Singh A, Chaudhary R, Sonker A, Pandey HC.

Importance of donor history of restless leg syndrome

and pica to assess iron deficiency. Transfus. Apr. Sci.

; 54(2): 259-61.

Goldman M, Magnussen K, Gorlin J, Lozano M.

International forum regarding practices related to

donor hemoglobin and iron. Vox Sang, 2016; 111(4):


Tailor HJ, Patel PR, Kumar A, Pandya NP, Mangukiya S.

Study of various hematological parameters and iron

status among voluntary blood donors. Int J Med.

Public Health, 2017; 7(1): 61-65.

Karakul O, Sommart P, Tolahan S, Poophapun W. Iron

Supplements and Iron Status in Frequent Blood

Donors. Hematol Transfus Int J. 2017; 5(3): 257‒260.

Reddy VK, Shastrya S, Raturic M, Poornima BB. Impact

of regular whole-blood donation on body iron stores.

Transfus Med Hemother, 2020; 47: 75–79.

Kiss JE, Vassallo RV. How do we manage iron deficiency

after blood donation?. British Journal of Haematology,

; 181: 590–603.

Lee SJ, Min HK, Jang JS, Lee S, Chung Y, Kim MJ. Donor

protection: Iron supplementation for frequent blood

donors in Korea. Trans and Aph Sci, 2020; 59: 102611.

DOI: http://dx.doi.org/10.24293/ijcpml.v27i3.1876


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.