Correlation between Mean Platelet Volume and Procalcitonin in Sepsis Patients
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https://doi.org/10.24293/ijcpml.v29i1.1917Keywords:
Mean platelet volume, procalcitonin, septic patientsAbstract
Sepsis is a clinical condition of potentially life-threatening organ dysfunction caused by the host's response to infection. Delayed diagnosis and treatment of sepsis lead to worsening of the disease, which can lead to circulatory collapse, multiple organ failure, and death, therefore accurate and timely diagnosis can prevent death. Procalcitonin (PCT) is the most widely used, studied, and promising marker for the diagnosis of sepsis. Recent studies have shown that procalcitonin plays an important role in the clinical diagnosis of sepsis because it can differentiate sepsis from SIRS. Most studies found an increase in the Mean Platelet Volume (MPV) in septic patients, both neonates, and adults. The MPV value can be used as a parameter to assess the prognosis of septic patients. This cross-sectional analytical study was conducted on 21 septic patients at Dr. M. Djamil Hospital, Padang from January 2020 to April 2021. Mean platelet volume values were determined using an automatic hematology analyzer based on the formula made by the device. Procalcitonin levels were measured using the enzym-linked immunofluorescent assay method. Data were analyzed by Pearson correlation test and p < 0.05 was significant. The mean age of the research subjects was 54 years and the range was 22-77 years. The number of male and female research subjects in this study was almost the same, consisting of 10 male (48%) and 11 female (52%) patients. The average MPV was 10.59(0.56) fL and the median procalcitonin was 9.35(2.08-200) ng/mL. Pearson correlation test showed that MPV was positively correlated with procalcitonin with moderate correlation (r=0.435, p=0.049). There was a moderate positive correlation between MPV and procalcitonin in septic patients.
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Ginting RA, Sembiring E, Rahimi A. Hubungan nilai Mean Platelet Volume (MPV) dengan derajat sepsis. Ilmu Penyakit Dalam Universitas Sumatera Utara. Dalam Majalah Kedokteran Nusantara, 2016; 49(2): 74-78.
Setiawan D, Harun H, Azmi S, Priyono D. Biomarker Acute Kidney Injury (AKI) pada sepsis. Jurnal Kesehatan Andalas, 2018; 7 (supplement 2): 113-118.
Wilar R, Antolis Y, Tatura SNN, Gunawan S. Jumlah trombosit dan mean platelet volume sebagai faktor prognosis pada sepsis neonatorum. Ilmu Kedokteran Anak Universitas Sam Ratulangi. Sari Pediatri, 2016; 12(1):53-57.
Arifin. Definisi dan kriteria diagnostik. Dalam penatalaksanaan sepsis dan syok septik optimalisasi fasthugsbid. PERDICI, 2017; 1-4.
Ä°rvem A, Aksaray S. Procalcitonin, C-reactive protein, leukocyte, mean platelet volume levels in bloodstream infections. J Clin Anal Med, 2018; 9(5): 391-5.
Husada D, Adnyana IGNT, Setyoningrum RA, Saharso D, Ismoedijanto. Akurasi diagnostik prokalsitonin sebagai petanda serologis untuk membedakan infeksi bakteri dan infeksi virus pada anak. Ilmu Kesehatan Anak Universitas Airlangga, Sari Pediatri, 2016; 13(5): 316-23.
Burnham CAD, Dorman T, Downing M, Hayden J, Langford BJ. The role of procalcitonin in diagnosis of sepsis and antibiotic stewardship: opportunities and challenges. Clinical Chemistry, 2017; 63(9): 1436–1441.
Aydemir C, Aydemir H, Kokturk F, Mungan AG. The cut-off levels of procalcitonin and C-reactive protein and the kinetics of mean platelet volume in preterm neonates with sepsis. BMC Pediatrics, 2018; 18: 253.
Gao Y, Li Y, Yu X, Guo S, Ji X, et al. The impact of various platelet indices as prognostic markers of septic shock.
PLos One, 2015; 9(8): e103761.
Cho SY, Yang JJ, Nam YS, Suh JT, Park TS, Lee HJ. Mean platelet volume in patients with increased procalsitonin level. Platelets, 2013; 24(3): 246-247.
Dursun A, Ozsoylu S, Akyildiz BN. Neutrophil-to -lymphocyte ratio and mean platelet volume can be useful markers to predict sepsis in children. Pak J Med Sci, 2018; 34(4): 918-922.
Puspitasari R, Saragih RC, Lubis M. Mean platelet volume sebagai faktor prognostik sepsis pada anak. Ilmu Kesehatan Anak Universitas Sumatera Utara, CDK, 2019; 276/46: 5.
Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, et al. An increase in mean platelet volume from baseline is associated with mortality in patiens with severe sepsis or septic shock. PLos One, 2015; 10(3): e0119437.
Djuang MH, Ginting F, Hariman H. Platelet indexes for bacterial sepsis severity assessment. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018; 24(3): 210-213.
Haryono S, Suryawan IWB, Widiasa AAM. Hubungan antara Mean Platelet Volume (MPV) dengan klinis sepsis neonatorum di RSUD Wangaya, Bali, Indonesia. Intisari Sains Medis, 2020; 11 (2): 675-679.
Indranila KS, Tjahjati DM, Emma. Procalcitonin dan interleukin-6 pada sepsis dengan gejala Systemic Inflammatory Response Syndrome (SIRS). Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018; 19(2): 98.
Intansari US, Dartini N, Kismardhani. Peramalan sepsis akibat procalcitonin terkait keluaran hasil klinis. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018; 20(2): 73-169.
Bounes FV, Gratacap MP, Groyer S, Ruiz S, Georges B, et al. Kinetics of mean platelet volume predicts mortality in patients with septic shock. PLos One, 2019; 14(10): e0223553.
Yang Y, Xie J, Guo F, Longhini F, Gao Z, et al. Combination of C-reactive protein, procalcitonin and sepsis-related organ failure score for the diagnosis of sepsis in critical patients. Intensive Care, 2016; 6: 51.
Tambajong RN, Lalenoh DC, Kumaat L. Profil penderita sepsis di ICU RSUP Prof. Dr. R. D. Kandou Manado periode Desember 2014 – November 2015. Jurnal e-Clinic (eCl), 2016; 4(1): 452-457.
Wardani IS. Tatalaksana sepsis berat pada pasien lanjut usia. Jurnal Kedokteran Unram, 2018; 7(4): 33-39.
Nasa P, Juneja D, Singh O. Severe sepsis and septic shock in the elderly: An overview. World J Crit Care Med, 2012; 20(4): 210-5.
Mayr FB, Yende S, Angus DC. Epidemiology of severe sepsis. Landes Biosciences, 2014; 5(1): 4-11.
Rahmawati P, Mayetti, Rahman S. Hubungan sepsis neonatorum dengan berat badan lahir pada bayi di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 2018; 7(3): 405-410.
Sakr Y, Elia C, Mascia L, Barberis B, Cardellino S, et al. The influence of gender on the epidemiology of and outcome from severe sepsis. Critical Care, 2013; 17: R50.
Lee H. Procalcitonin as a biomarker of infectious diseases. Korean J Intern Med, 2013; 28: 285-291.
Wahyuddin F. Akurasi diagnostik prokalsitonin sebagai penanda serologis untuk membedakan antara sepsis bakterial dan virus. 2017. Available from: www.digilib.unhas.ac.id (accessed May 8, 2020).
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