Survival Study of D-dimer, Lactic Acid and BGA on COVID-19 Patients
DOI:
https://doi.org/10.24293/ijcpml.v29i1.1966Keywords:
Blood gas analysis, COVID-19, D-dimer, lactic acid, prognostic factorAbstract
The value of D-dimer value, lactic acid levels, and the results of blood gas analysis (PaO2, PCO2, PH, and PaO2/FiO2) are prognostic factors for COVID-19 patients, although there is no agreement on the optimum cut-off point for specificity and sensitivity. The aim of this study is to examine D-dimer value, lactic acid levels, and the results of blood gas analysis as a prognosis for patients with severe or critical COVID-19. This was a retrospective study of the medical records of the UGM Academic Hospital. Overall survival was assessed by the Kaplan-Meier curve. Determination of the cut-off for D-dimer, lactic acid, and BGA variables was carried out using the ROC followed by calculating the Youden index. Then the hazard ratio was determined by Cox regression. The cut-off value to determine the group of patients on the D-dimer and lactic acid variable was 881 ng/mL (sensitivity 77.23%, specificity 32.31%) (p=0.040) and 21 ng/mL, patients with lactic acid values above the cut-off had a higher risk of death (p=0.391). The cut-off of pH, PaO2, and PaCO2 were 7.43, 72.2 mmHg, and 33.9, respectively. D-dimer levels, lactic acid, and PaCO2 values in blood gas analysis above the cut-off value had a worse survival rate, while patients also had a worse survival rate if the PaO2 and PH values were below the cut-off value.
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References
Archived: Who timeline - covid-19. (n.d.). Available from: https://www.who.int/news/item/27-04-2020
-who-timeline---covid-19 (accessed Feb 17, 2021).
Timeline: Who's Covid-19 response. (n.d.). Available from: ttps://www.who.int/emergencies/diseases/
novel-coronavirus-2019/interactive-timeline#! (accessed Feb 17, 2021).
Who coronavirus disease (covid-19) dashboard. (n.d.). Available from: https://covid19.who.int/(accessed Feb 17, 2021).
COVID-19, S. (n.d.). Peta sebaran. Available from: https://covid19.go.id/peta-sebaran (accessed Feb 17, 2021).
Betti M, Bertolotti M, Ferrante D, Roveta A, Pelazza C, Giacchero F. Baseline clinical characteristics and
prognostic factors in hospitalized COVID-19 patients aged ≤ 65 years: A retrospective observational study. PLos One, 2021; 16(3): e0248829.
Thomson RJ, Hunter J, Dutton J, Schneider J, Khosravi M, et al. Clinical characteristics and outcomes of
critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective
observational cohort study. PLos One, 2020; 15(12): e0243710.
Rostami M, Mansouritorghabeh H. D-dimer level in COVID- 19 infection: A systematic review. Expert
Review of hematology 2020; 13(11): 1265–1275.
Bezuidenhout MC, Wiese OJ, Moodley D, Maasdorp E, Davids MR, et al. Correlating arterial blood gas,
acid–base and blood pressure abnormalities with outcomes in COVID-19 intensive care patients. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2020; 58(2): 95–101.
Wang K, Qiu Z, Liu J, Fan T, Liu C, et al. Analysis of the clinical characteristics of 77 COVID-19 deaths.
Scientific Reports, 2020; 10: 1.
Nardi G, Sanson G, Tassinari L, Guiotto G, Potalivo A, et al. Lactate arterial-central venous gradient among COVID-19 patients in ICU: A potential tool in the clinical practice. Critical Care R e s e a r c h a n d
Practice, 2020; 1–5.
Bahl A, Van Baalen MN, Ortiz L, Chen NW, Todd C, et al. Early predictors of in-hospital mortality in patients with COVID-19 in a large American cohort. Internal and Emergency Medicine, 2020; 15(8): 1485–1499.
Bezuidenhout MC, Wiese OJ, Moodley D, Maasdorp E, Davids MR, et al. Correlating arterial blood gas,
acid–base and blood pressure abnormalities with outcomes in COVID-19 intensive care patients. Annals
of Clinical Biochemistry: International Journal of Laboratory Medicine, 2020; 58(2): 95–101.
Chhetri S, Khamis F, Pandak N, Al Khalili H, Said E, Petersen E. A fatal case of COVID-19 due to metabolic acidosis following dysregulate inflammatory response (cytokine storm). ID Cases, 2020; 21: e 00829.
Pulgar-Sanchez M, Chamorro K, Fors M, Mora FX, Ramires H, et al. Biomarkers of severe COVID-19
pneumonia on admission using data-mining powered by common laboratory blood tests-datasets. Comput Biol Med, 2021; 136: 104738.
Muley A, Chordiya R, Gill R, Pandya H, Kapadia S, Lakhani J. Arterial blood gas analysis of critically ill
Coronavirus disease 2019 patients. Asian Journal of Research in Infectious Diseases, 2021; 51-6.
Bezuidenhout MC, Wiese OJ, Moodley D, Maasdorp E, Davids MR, et al. Correlating arterial blood gas, acidbase and blood pressure abnormalities with outcomes in COVID-19 intensive care patients. Ann Clin
Biochem, 2021; 58: 95-101.
Balzanelli GM, Distratis P, Aityan KS, Amatulli F, Catucci O, et al. Clinical features in predicting COVID-19. Biomedical Journal of Scientific & Technical Research, 2020; 29.
Choron RL, Butts CA, Bargoud C, Krumrei NJ, Teichman AL, et al. Fever in the ICU: A predictor of mortality in mechanically ventilated COVID-19 patients. J Intensive Care Med, 2021; 36: 484-93.
Shevel E. Conditions favoring increased COVID-19 morbidity and mortality: Their common denominator and treatment. Isr Med Assoc J, 2020; 11(22): 68.
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