Analysis of the D-dimer/Platelets Ratio in Sepsis Patients at Dr. Wahidin Sudirohusodo Hospital Makassar

Authors

  • Yarianti Yarianti Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo Hospital, Makassar
  • Darwati Muhadi Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo Hospital, Makassar
  • Agus Alim Abdullah Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Labuang Baji Hospital, Makassar

DOI:

https://doi.org/10.24293/ijcpml.v30i2.2149

Keywords:

Sepsis, mortality, D-dimer, platelets

Abstract

Sepsis is a condition with a life-threatening organ dysfunction. This condition is caused by a dysregulated host response to infection. This study aimed to determine the ratio and cut-off value of D-dimer/platelets in sepsis patients. This study was a cross-sectional observational study. This study took secondary data from the medical records of 142 patients at Dr. Wahidin Sudirohusodo Hospital (RSWS) from January 2018 to December 2021. The results of this study showed that the D-dimer/platelet ratio was significantly higher in those who died (mean 0.151) compared to those who survived (mean 0.028) (p<0.015) with a cut-off value of 0.020.

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References

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 2016; 315(8): 801-810.

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: Analysis for the global burden disease study. Lancet, 2020; 395(10219): 200-211.

Semeraro N, Ammollo CT, Semeraro F, Colucci M. Coagulopathy of acute sepsis. Semin Thromb Hemost, 2015; 41: 650-658.

Johnson ED, Schell JC, Rodgers GM. The D-dimer assay. Am J Hematol, 2019; 94: 833-839.

Han YQ, Yan L, Zhang L, Ouyang PH, Li P, et al. Performance of D-dimer for predicting sepsis mortality in the intensive care unit. Biochem Med (Zagreb), 2021; 31(2): 020709.

Vardon-Bounes F, Ruiz S, Gratacap M, Garcia C, Payrastre B, et al. Platelets are critical key players in sepsis. Int. J. Mol. Sci, 2019; 20: 3494.

Giustozzi M, Ehrlinder H, Bongiovanni D, Borovac JA, Guerreiro RA, et al. Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment. Blood Reviews, 2021; 50: 100864.

Bedet A, Razazi K, Boissier F, Surenaud M, Hue S, et al. Mechanisms of thrombocytopenia during septic shock: A multiplex cluster analysis of endogenous sepsis mediators. Shock, 2018; 49(6): 641-648.

Greco E, Lupia E, Bosco O, Vizio B, Montrucchio G, et al. Platelets and multi-organ failure in sepsis. Int. J. Mol. Sci, 2017; 18: 2200.

Li X, He Y, Shang Y, Yang Y, Wang M, et al. D-dimer-to-platelet ratio as a novel marker of in-hospital adverse outcomes among patients with acute pulmonary embolism: A single-center retrospective study. Research Square, 2021; 11(03): rs281239.

Puspitasari Y, Aryati, Hajat A, Semedi BP. Relationship between D-dimer level and clinical severity of sepsis. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2017; 23(3): 216-220.

Velez JW, Aragon DC, Donadi EA, Carlotti APCP. Risk factors for mortality from sepsis in an intensive care unit in Ecuador. A prospective study. Medicine, 2022; 101: 00(e29096).

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Submitted

2023-05-15

Accepted

2023-06-12

Published

2024-02-16

How to Cite

[1]
Yarianti, Y., Muhadi, D. and Abdullah, A.A. 2024. Analysis of the D-dimer/Platelets Ratio in Sepsis Patients at Dr. Wahidin Sudirohusodo Hospital Makassar. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 30, 2 (Feb. 2024), 187–190. DOI:https://doi.org/10.24293/ijcpml.v30i2.2149.

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