Correlation between VCAM-1 Level and Absolute Monocyte Count in Coronary Artery Disease
DOI:
https://doi.org/10.24293/ijcpml.v30i3.2201Keywords:
VCAM-1, absolute monocyte count, CADAbstract
To prove the correlation between VCAM-1 level and absolute monocyte count among Coronary Artery Disease (CAD) patients. The study was an observational analytic study with a cross-sectional approach. The research subjects were 74 CAD patients who had been proven by coronary angiography and were treated in the Cardiology Department of Central General Hospital by Dr. Kariadi Semarang. This study was conducted from March to July 2021. VCAM-1 levels were examined with the ELISA method, using BioTek ELX800 Microplate reader (USA), and absolute monocyte count was analyzed with flow cytometry method, using Hematology Analyzer SYSMEX XN-1000 (Japan). Statistical analysis was done by Pearson's correlation coefficient test, in which p<0.05 was considered significant. The mean VCAM-1 level was (361.78±128.01) ng/mL. The mean absolute monocyte count was (0.48±0.17) ×103/µL. The result of the Pearson correlation test showed a moderate positive correlation between VCAM-1 levels and absolute monocyte count in CAD patients (p=0.00; r=0.46). There was a moderate positive correlation between VCAM-1 level and absolute monocyte count in CAD patients. A positive correlation exists between VCAM-1 level and absolute monocyte count among CAD patients.
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References
Wang H, Liu Z, Shao J, Jiang M, Lu X, et al. Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants. Genes Dis, 2020; 15–32.
Mack M, Gopal A. Epidemiology, traditional and novel risk factors in coronary artery disease. Heart Fail Clin, 2016; 12(1): 1–10. Available from: http://dx.doi.org/10.1016/j.hfc.2015.08.002 (accessed Jan 27, 2024).
Arnold SV, Bhatt DL, Barsness GW, Beatty AL, Deedwania PC, et al. Clinical management of stable coronary artery disease in patients with type 2 diabetes mellitus: A scientific statement from the American Heart Association. Circ, 2020; 141: 00–00.
Firdaus I. Hari Jantung Sedunia (World Heart Day): Your heart is our heart too. Perhimpunan Dokter Spesialis Kardiovaskular Indonesia. 2019. Available from: http://www.inaheart.org/news_and_events/news/2019/9/26/press_release_world_heart_day_perki_2019 (accessed Jan 27, 2024).
Santos HO, Izidoro LFM. Neutrophil-lymphocyte ratio in cardiovascular disease risk assessment. Int J Cardiovasc Sci, 2018; 31(5): 532–7.
Kim KW, Ivanov S, Williams JW. Monocyte recruitment, specification, and function in atherosclerosis. Cells, 2020; 10(1): 15.
Helen W, Mack CD, Li SCH, Fletcher JP, Medbury HJ. Nature versus number: monocytes in cardiovascular disease. Int. J. Mol. Sci. 2021; 22(17), 9119.
Song FH, Zheng YY, Tang JN, Wang W, Guo QQ, et al. A correlation between monocyte to lymphocyte ratio and long-term prognosis in patients with coronary artery disease after PCI. Clin Appl Thromb Hemost, 2021; 27: 107-120.
Ismawati I, Romus I, Mukhyarjon M, Muthya A. Effect of proteasome inhibitor on Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1) expressions in rat model of atherosclerosis. Biochemistry & Molecular Biology, 2022; 10(4): 633.
de Freitas IA, de Alcantara Lima N, da Silva Jr GB, de Castro Jr RL, Patel P, et al. Novel biomarkers in the prognosis of patients with atherosclerotic coronary artery disease. Revista Portuguesa de Cardiologia (English Edition). 2020; 39(11):667-72.
Fu Y, Wu Y, Liu E. C reactive protein and cardiovascular disease: From animal studies to the clinic. Exp Ther Med, 2020; 20(2): 1211-9.
Calabriso N, Massaro M, Scoditti E, Carluccio C, Verri T, et al. Epigenetic mechanisms in vascular inflammation: modulation of endothelial adhesion molecules and endothelium-leukocyte adhesion. Frontiers in Bioscience-Landmark, 2023; 28(9): 194.
Leite AR, Borges-Canha M, Cardoso R, Neves JS, Castro-Ferreira R, et al. Novel biomarkers for evaluation of endothelial dysfunction. Angiology, 2020; 71(5): 397-410.
Saiki P, Yoshihara M, Kawano Y, Miyazaki H, Miyazaki K. Anti-inflammatory effects of Heliangin from Jerusalem Artichoke (Helianthus tuberosus) leaves might prevent atherosclerosis. Biomolecules, 2022; 12(1): 91.
Sanin DE, Ge Y, Marinkovic E, Kabat AM, Castoldi A, et al. A common framework of monocyte-derived macrophage activation. Sci. Immunol, 2022; 7(70): 74-82.
Belcastro E, Rehman AU, Remila L, Park SH, Anton N, et al. Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells. Nanomed J, 2021; 34: 102-110.
Zhao Y, Zhang J, Zhang W, Xu Y. A myriad of roles of dendritic cells in atherosclerosis. CEI, 2021; 206(1): 12-27.
Poznyak AV, Bharadwaj D, Prasad G, Grechko AV, Sazonova MA, et al. Anti-inflammatory therapy for atherosclerosis: focusing on cytokines. Int. J. Mol. Sci, 2021; 22(13): 7061.
Vrablik M, Corsini A, Tumova E. Beta-blockers for atherosclerosis prevention: A missed opportunity?. Curr. Atheroscler. Rep, 2022; 24(3): 161-9.
Cheng H, Zhong W, Wang L, Zhang Q, Ma X, et al. Effects of shear stress on vascular endothelial functions in atherosclerosis and potential therapeutic approaches. Biomed. Pharmacother, 2023; 158: 114198.
Shi-Hui Law, Mei-Lin Chan, Gopal K. Marathe, Farzana Parveen C-HC, L-YK. An updated review of lysophosphatidylcholine metabolism in human disease. Int J Mol Sci, 2019; 20: 150-9.
SahBandar IN, Ndhlovu LC, Saiki K, Kohorn LB, Peterson MM, et al. Relationship between circulating inflammatory monocytes and cardiovascular disease measures of carotid intimal thickness. J Atheroscler Thromb, 2020; 27(5): 441-8.
Thayse K, Kindt N, Laurent S, Carlier S. VCAM-1 Target in non-invasive imaging for the detection of atherosclerotic plaques. Biology, 2020; 9(11): 368.
Marziah E, Adi Koesoema Aman, Andre Pasha Ketaren. Correlation between platelet to lymphocyte ratio and coronary artery narrowing. Indonesian Journal of Clinical Pathology and Medical Laboratory, 2018; 24(3): 219-222.
Troncoso MF, Ortiz-Quintero J, Garrido-Moreno V, Sanhueza-Olivares F, Guerrero-Moncayo A, et al. VCAM-1 as a predictor biomarker in cardiovascular disease. BBA Molecular Basis of Disease, 2021; (9): 166-170.
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