KADAR N TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE PADA PENDERITA PENYAKIT JANTUNG HIPERTENSI

Abstract

Patients with hypertension are at high risk for development of Left Ventricle Hypertrophy (LVH) and Left Ventricular Systolic
Dysfunction (LVSD). These conditions should be identified earlier to prevent cardiac morbidity and mortality. To measured serum
level of NT-proBNP in hypertensive and mild symptomatic Hypertensive Heart Disease (HHD) patients (NYHA class I-II), to perform
echocardiography evaluation to all of the patients and associated with serum level of NT-proBNP. A cross sectional study was done at H.
Adam Malik Hospital Medan, participants were recruited from consecutive samples of 15 hypertensive and 16 mild symptomatic HHD
patients whose visited cardiovascular and internal medicine out patient clinics. Of these patients, blood samples were taken and a two
dimension echo-Doppler study was performed. The patients divided into three groups based on echocardiography studies respectively:
Group 1: 9 hypertensive patients with normal echocardiography finding; group 2: 13 patients with LVH and ejection fraction (EF) ≥
60%; and group 3: 9 patients with LVH and EF < 60%. Mean NT-proBNP serum level (in pg/mL) for groups 1-3 respectively, were:
56.4 ± 34.5, 245.4 ± 339.2 and 852.0 ± 1218.9. Mean NT-proBNP serum level differed among all three groups (p = 0.050), but
the significant difference found between group 1 and group 3 (p < 0.05) only. There were significant correlation between NT-proBNP
serum level and the three stages of echocardiography finding (r = 0.488 and p = 0.005). The result suggests that NT-proBNP serum
level correlated with deterioration of heart function and structure according echocardiography studies. The Significant rise in NT-proBNP
serum level happened only when Left Ventricular Systolic Dysfunction (LVSD) develops in hypertension.