ANALISIS KADAR ASAM URAT PADA PASIEN KARSINOMA MAMMA

Susi Sevianty, Uleng Bahrun, Mansyur Arif

Abstract


In malignancy cases, an increase of uric acid level is often observed after therapy (Tumor Lysis Syndrome), but some studies also
indicated an increase before therapy which is related to a refusal reaction against tumor, and specific only for certain malignancy cases.
Carsinoma mammae is the second most common malignancy among women in Indonesia, so that studying the phenomenon occurred
in carcinoma mammae including uric acid level are expected to provide insight in management of carcinoma mammae. A longitudinal
study was conducted by collecting secondary data from medical record of carcinoma mammae patients in Wahidin Sudirohusodo
Hospital for period of July 2007–June 2008. Data were analyzed by using Wilcoxon Signed Rank Test with alpha 0.05. 12 of subjects
are considered eligible for study criteria, with the age ranging from 28–60 years old. In generally, uric acid level determined before
and after chemotherapy showed a level in normal range, except for 3 samples before therapy and 3 different samples after therapy
showed a level more than 5.7 mg/dL. Statistic result showed mean uric acid level before chemotherapy was 4.508 ± 1.2566 mg/dL and
after chemotherapy was 5.025 ± 1.3240 mg/dL (p = 0.16). Increased of uric acid level is not significant level was found in serum of
carcinoma mammae before and after chemotherapy.


Keywords


carcinoma mammae, uric acid

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DOI: http://dx.doi.org/10.24293/ijcpml.v16i1.992

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