, DALAM KEADAAN (STATUS) IMUNOLOGIS DAN KLINIS PENGOBATAN ANTIRETROVIRAL PENDERITA HIV/AIDS CD38 LIMFOSIT CD8 + , TAMPANG (PROFIL) CD4 +

Ira Puspitawati, Umi S. Intansari

Abstract


ABSTRACT
The relationship between immune activation and pathogenesis of Human Immunodeficiency Virus (HIV) infection is unproven. It
has been hypothesized that state that HIV-induced activation enhances the magnitude of HIV replication other study shown that viral
replication impaired immune activation. One of the best immune activation marker is CD38 expression on CD8
because it has the
strongest significant prognostic markers. It was previously shown that increased CD8
+
T-cell activation has predictive value for disease
progression but the relation is still controversial. One hypothesis state that HIV-induced activation enhances the magnitude of HIV
replication, other said that viral replication impaired immune activation. To know the profile of immunology and clinical state of HIV/
AIDS patients by determining the CD38 molecule expression on CD8
+

profiles and clinical state.
Crosssectonal, observasional study was done. Twenty nine HIV/AIDS patients who routinely had medical check up and having routine

+
cells as an activation marker, CD4
+
antiretroviral therapy at Sardjito hospital and 8 healthy people as normal controls were involved in this study. The count of CD4

+
cells

counts had significant
negative correlation with WHO stage (p = 0.012). Expression of CD38 molecule on CD8
absolute counts and expression of CD38 molecule on CD8

cells were measured using flowcytometry. The CD4
+
cells of HIV/AIDS patients were higher
compared to normal controls, 209.29 ± 76.56, 109.61 + 32.29 respectively (p < 0.05). That expression was not correlated with CD4

+


+
counts and CD4
increment
after therapy was statistically significant (p = 0.003). The CD4
+
increment. It might be caused by the time of measurement was not at the begining of diseases. The CD4

+

count was negatively correlated with the WHO stage. Expression of
CD38 molecule on CD8
+

cells of HIV/AIDS patients were significantly higher compared to normal controls but it wasn’t correlated with
the CD4
+
+

number and CD4
+
increment after therapy.


Keywords


CD38, immune activation, HIV/AIDS, CD8 + cells, CD4 + cells

Full Text:

PDF


DOI: http://dx.doi.org/10.24293/ijcpml.v16i1.994

Refbacks

  • There are currently no refbacks.